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Testosterone Metabolism in Idiopathic Hirsutism

JOHN J. DELLER JR.; LAURENCE C. WEGIENKA, M.D.; NICHOLAS F. CONTE; JORGE M. ROSNER, M.D.; and PETER H. FORSHAM, M.D.
Ann Intern Med. 1965;63(3):369-376. doi:10.7326/0003-4819-63-3-369
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The recent development of methods for measuring testosterone in both the blood and the urine (1-6) has made possible a new approach to the problem of diagnosis in idiopathic hirsutism. This paper describes studies in 35 cases of hirsutism of various causes, including some that must still be classified as "idiopathic," and 15 appropriate control cases. The dynamics of testosterone metabolism were studied in these women during stimulation and suppression of the adrenals and ovaries. In addition to testosterone, urinary 17-hydroxycorticosteroids (17-OHCS), 17-ketosteroids (17-KS), creatinine, and pregnanetriol were measured. The value of urinary testosterone studies in the evaluation of idiopathic

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