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Primary Chief Cell Hyperplasia of the Parathyroid Glands

P. H. ADAMS, M.B., M.R.C.P.; T. M. CHALMERS, M.D., F.R.C.P.; N. PETERS, M.B., M.R.C.P.; J. H. RACK, M.B., M.C. PATH.; and B. MCN. TRUSCOTT, M.B., F.R.C.S.
Ann Intern Med. 1965;63(3):454-467. doi:10.7326/0003-4819-63-3-454
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This excerpt has been provided in the absence of an abstract.

The association of enlarged parathyroid glands and bone disease has long been recognized, but it has frequently been found difficult to distinguish between hyperplasia of the glands and neoplasm. Moreover the difference between primary disease of the parathyroid glands and enlargement secondary to renal or other diseases was not clear to earlier writers. For these reasons it is usually difficult to classify the cases reported in the early literature although the reports of Strada (1) and Kerl (2) probably refer to primary hyperplasia of the parathyroids.

The first satisfactory description of primary parathyroid hyperplasia was given by Albright, Bloomberg, Castleman,


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