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Adrenal Hemorrhage During Anticoagulant Therapy: A Clinical and Pathological Study of Ten Cases

Ann Intern Med. 1965;63(4):559-571. doi:10.7326/0003-4819-63-4-559
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Adrenal hemorrhage caused by septicemia is a well-recognized entity (1, 2). Its iatrogenic counterpart produced by anticoagulant therapy may be equally frequent and fatal, as suggested by the increasing number of case reports (3-17). It has not, however, been studied systematically and hence is seldom recognized during life.

In this study the clinical course and pathology of iatrogenic adrenal hemorrhage and its frequency relative to that caused by known predisposing disease were defined in a series of consecutive autopsies performed since the adoption of anticoagulant therapy. The clinical manifestations of the 10 cases encountered and of the 20 reported previously


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