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Clinical and Epidemiological Features of Coxsackie Group B Virus Infections

Ann Intern Med. 1965;63(4):597-603. doi:10.7326/0003-4819-63-4-597
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Since Dalldorf and Sickles (1) first described Coxsackie viruses in 1948, 30 distinct serotypes have been identified. Twenty-four are classed in group A and six in group B by characteristic pathology produced by infection of the suckling mouse (2, 3). Since then the group A viruses have been found to cause herpangina and central nervous system disease of varied clinical manifestations (3, 4). The group B viruses have generally been recognized to produce epidemics of aseptic meningitis and pleurodynia and to cause encephalomyocarditis in infants. The group B Coxsackie viruses have also been implicated in a number of other clinical


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