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Changes in Body Composition During Weight Reduction in Obesity: Balance Studies Comparing Effects of Fasting and a Ketogenic Diet

Ann Intern Med. 1965;63(4):604-612. doi:10.7326/0003-4819-63-4-604
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Utilization of prolonged fasting as a means of weight reduction in obesity has been extensively evaluated (1-3) and found to produce a consistent, adequate weight loss. Few reports have focused on the changes in gross body composition that accompany a period of fasting or compared such changes to those obtained with other dietary reducing programs. Although it is known that large losses of body potassium occur during the total fast (3), this has not been correlated with lean body changes. Since the bulk of body potassium is present in muscle, with only minimal concentration in fat (4), losses of the


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