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Metabolic Effects of Dietary Protein in Chronic Renal Failure

Ann Intern Med. 1965;63(4):642-653. doi:10.7326/0003-4819-63-4-642
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Since the time of Richard Bright, protein restriction has been widely advocated in the treatment of chronic renal failure (1-7). Evidence, however, that such dietary management actually improves renal function in azotemia is scarce.

On the contrary, much animal data has accumulated to indicate that renal function varies directly with protein intake; that is, the greater the dietary protein, the better the filtering ability of the kidney. Glomerular filtration rate (GFR), as measured by urea clearance, has been found to rise 100% after a meat meal in a normal dog that had previously been on a low protein diet (8);


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