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Cytologic Dysplasia Occurring After Busulfan (Myleran⌖) Therapy: A Syndrome Resembling Adrenocortical Insufficiency and Atrophic Bronchitis

Ann Intern Med. 1965;63(4):654-660. doi:10.7326/0003-4819-63-4-654
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In 1956 Marinho and Martins (1) first called attention to a syndrome resembling adrenocortical insufficiency that occurred after busulfan (Myleran⌖) therapy in two patients with chronic granulocytic leukemia. In 1961 Kyle, Schwartz, Oliner, and Dameshek (2) reported four patients with chronic granulocytic leukemia who developed a similar syndrome after long-term busulfan therapy. In all of Kyle's patients there were hyperpigmentation of the skin, excessive fatigue, weakness, weight loss, nausea, and occasional vomiting. However, no endocrine abnormality could be demonstrated by laboratory tests. Cytologic dysplasia may also occur after treatment with antileukemic agents as reported by Weston and Guin (3) in


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