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Salivary Gland Enlargement Caused by Sulfisoxazole

Ann Intern Med. 1965;63(4):663-665. doi:10.7326/0003-4819-63-4-663
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A wide variety of toxic and allergic reactions have been associated with the administration of sulphonamides (1). A recent patient was observed who developed salivary gland enlargement on four separate occasions after the administration of sulfisoxazole; to our knowledge this reaction to a sulphonamide has not been reported previously.

CASE REPORT: A 72-year-old Negro female was admitted to the hospital after collapsing at home. Neurological examination (on this admission) revealed rightsided weakness, a right extensor plantar sign, mild confusion, dysarthria, and a left homonymous hemianopsia. The blood pressure was 160/100 mm Hg; the remainder of the physical exam was within


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