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Lung Purpura and Nephritis (Goodpasture's Syndrome) Complicated by the Nephrotic Syndrome

V. R. BLOOM, B.M.; D. J. WAYNE, B.M.; and O. M. WRONG, D.M.
Ann Intern Med. 1965;63(5):752-759. doi:10.7326/0003-4819-63-5-572
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The Association of a Hemorrhagic lung disorder with glomerulonephritis was described by Goodpasture in 1919 (1). The term "Goodpasture's syndrome" was coined by Stanton and Tange (2) when they reported nine other cases with this association, but Rusby and Wilson (3) preferred the term "lung purpura with nephritis" for their five cases.

The typical clinical picture is of a young adult male with a rapidly fatal glomerulitis that has many of the features of the 'subacute course' of glomerulonephritis described by Volhard and Fahr (4) and that is either preceded or complicated by repeated and profuse hemoptysis. The following five

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