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Parathyroid Hormone-secreting Renal Carcinoma Associated with Hypercalcemia and Metabolic Alkalosis

Ann Intern Med. 1965;63(5):858-868. doi:10.7326/0003-4819-63-5-858
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Hypercalcemia without bone metastasis is an unusual systemic manifestation of neoplastic disease (1-22). In 1936, Gutman, Tyson, and Gutman (1) described a case of bronchogenic carcinoma with unexplained hypercalcemia which, aside from a localized area of Paget's disease, had normal bones at autopsy. Albright and Reifenstein (2, 3) subsequently described a case of renal carcinoma with a single pelvic metastasis and serum calcium and phosphorus values similar to those found in hyperparathyroidism. Irradiation of the pelvic metastasis transiently corrected the chemical abnormalities suggesting to them the possibility of a parathyroid hormone-secreting neoplasm. This theory was supported in 1956 by Plimpton


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