From 1950 to 1963 a diagnosis of infectious mononucleosis was made in 1,285 cases at the Mayo Clinic. This is a review of 13 cases with nervous system involvement that had detailed neurologic evaluation and met the hematologic, serologic, and clinical requirements for a diagnosis of infectious mononucleosis. This group included 11 males and 2 females with an age range of 11 to 25 years.
Of 13 cases, 8 had an acute meningo-encephalomyelitis of short duration characterized by headache, fever, stiff neck, delirium, and confusion. Additional manifestations in some included combative and irrational behavior, seizures, papilledema, and signs of cerebellar