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Abstracts |

Diffuse Interstitial Fibrosis: An Appraisal of Therapy.

Asher Marks, M.D. (Associate)
Ann Intern Med. 1965;63(5):918-919. doi:10.7326/0003-4819-63-5-918_3
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Fifteen years ago Austrian described a group of diseases comprising an "alveolar-capillary block" syndrome. Criteria for inclusion were: diffuse, finely dispersed radiographic lesions, essentially normal dynamic ventilatory function, and measured impairment of alveolar-capillary gas exchange. Although the concept of pure diffusion abnormalities has been recently challenged, increasing numbers of patients and diseases are described in which diffuse pulmonary interstitial abnormalities are associated with the enumerated abnormalities. At present well over 100 different disease entities have been described. A large segment of these patients is comprised of individuals with diffuse interstitial fibrosis of unknown etiology. Although the similar histologic appearance does


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