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Diffuse Interstitial Pulmonary Disease: Pathophysiology and Steroid Therapy.

Jerome E. Cohn, M.D., F.A.C.P.
Ann Intern Med. 1965;63(5):919. doi:10.7326/0003-4819-63-5-919_1
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Clinical and physiological investigations were performed in 20 patients having diffuse nodular and linear densities in chest roentgenograms. Pathologic diagnoses were established by lung biopsy or autopsy: nonspecific fibrosis, Hamman-Rich disease, sarcoidosis, eosinophilic granuloma of lung, postirradiation fibrosis, and probable periarteritis.

Pulmonary functions were measured before a biopsy or treatment. Seventeen subjects had normal ventilatory function and expiratory flow velocity, and two exhibited moderately severe obstructive airway disease. Inspiratory capacity was reduced in eight, each of whom had a small vital capacity. Lung compliance was very low in 11 and normal in 5. Intrapulmonary distribution of blood and gas was


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