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The Relation of Capillary Angiopathy and Diabetes Mellitus to Idiopathic Edema

Ann Intern Med. 1965;63(6):972-987. doi:10.7326/0003-4819-63-6-972
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There has long been recognized a group of patients who are prone to develop edema but in whom none of the obvious causes, such as cardiac failure, hypoproteinemia, renal disease, or allergic reactions, can be implicated (1-3). This syndrome has come to be known as idiopathic edema and is seen most often in premenopausal women who are somewhat overweight and who exhibit considerable tension and emotional lability. Some, however, including many of those in the present series, are neither obese nor emotionally labile. Retention of fluid occurs erratically and is at times marked, but it is not synchronized with the


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