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Familial Amyloid-producing Medullary Thyroid Carcinoma and Pheochromocytoma: A Distinct Genetic Entity

Ann Intern Med. 1965;63(6):1027-1039. doi:10.7326/0003-4819-63-6-1027
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Considerable attention has of late been focused on heritable disorders of the endocrine system. The inborn errors of thyroid and adrenal metabolism have been fairly well characterized and have been the subjects of recent reviews (1, 2). Although the exact mode of inheritance remains to be established, diabetes mellitus appears to have a strong genetic component. Multiple endocrine adenomas, primarily involving pituitary, pancreas, and parathyroids, have also been described in multiple members of some families (3), and the syndrome appears to be genetically well defined (4). Pheochromocytoma has likewise been found to occur in familial aggregates, either alone (5) or


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