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Response to Sodium Fluoride in Severe Primary Osteoporosis

Ann Intern Med. 1965;63(6):1069-1074. doi:10.7326/0003-4819-63-6-1069
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It has been shown from epidemiological studies that a moderate intake of fluoride will eventually cause osteosclerosis that is not associated with significant morbidity except in the most extreme cases (1-3). Because of this and because it is reasonable to suppose that any measure that substantially increases bone mass will reverse the course of osteoporosis, we evaluated sodium fluoride several years ago as a possible form of treatment of this disease (4). In this early work and in recently published studies (5), we found that most patients with osteoporosis or Paget's disease retained calcium, and no significant toxic effects were


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