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A Study of Bacillus Calmette-Guérin Vaccination and the Kveim Reaction

HAROLD L. ISRAEL, M.D., F.A.C.P.; and MAURICE SONES, M.D., F.A.C.P.
Ann Intern Med. 1966;64(1):87-91. doi:10.7326/0003-4819-64-1-87
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A majority of patients with active sarcoidosis develop a granulomatous nodule within 6 weeks of the intracutaneous injection of suspensions prepared from spleens or lymph nodes involved by sarcoidosis. Clinical use of the Kveim reaction as a diagnostic test has been limited by difficulties in preparation and biologic standardization that seriously restrict the availability of test materials, by a hazard of deterioration resulting in loss of potency or of specificity, and by the fact that a significant number of patients with active sarcoidosis fail to react to suspensions of unquestioned potency. The Kveim reaction is nevertheless of basic importance, apparently

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