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Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute Leukemia

GERALD P. BODEY, M.D.; MONICA BUCKLEY, B.A.; Y. S. SATHE, PH.D.; and EMIL J FREIREICH, M.D.
Ann Intern Med. 1966;64(2):328-340. doi:10.7326/0003-4819-64-2-328
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This excerpt has been provided in the absence of an abstract.

Infection is currently the major fatal complication of acute leukemia (1). Previous studies have indicated a relationship between leukopenia and the presence of infection in patients with acute leukemia (2-4) and various types of agranulocytosis (5-7). Chemotherapeutic agents with bone marrow toxicity are being used with increasing frequency in malignant and other chronic diseases. Also, a high incidence of infection has accompanied the use of these agents as immunosuppressive therapy in patients receiving organ transplantation (8). The present study examines the quantitative relationships between the presence of infection and the degree and duration of leukopenia in patients with acute leukemia.

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