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Hypercalcemia and Hypertension

Ann Intern Med. 1966;64(2):378-381. doi:10.7326/0003-4819-64-2-378
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Hypertension as a sign of hypercalcemia has received little emphasis in the literature. Many current textbooks of medicine and endocrinology fail to mention the association while stressing rarer manifestations of hypercalcemia such as pancreatitis. This paper reviews recent experience with three consecutive patients with hypercalcemia and reversible hypertension. Recent experimental evidence confirming the importance of calcium ion concentration on peripheral vascular tone is discussed.

CASE REPORTS: CASE 1A 24-year-old Negro man underwent a subtotal thyroidectomy in May, 1963, for Graves' disease. Postoperatively he developed hypoparathyroidism which was treated with vitamin D and calcium lactate. He was admitted to the


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