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Fixed and Reproducible Orthostatic Proteinuria: V. Results of a 5-Year Follow-up Evaluation

Ann Intern Med. 1966;64(3):557-569. doi:10.7326/0003-4819-64-3-557
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Although orthostatic proteinuria has been traditionally regarded as a benign and transient condition of adolescence (1-6), recent observations have indicated that this long-standing clinical opinion may be incorrect (7-11). In particular, it has been suggested that the "fixed and reproducible" form of orthostatic proteinuria may reflect an early manifestation of underlying renal disease (7-10). This concept has largely arisen from the demonstration that this type of proteinuria is more apt to persist than disappear (7), that obvious signs of renal disease may appear in some patients within a few years (7), and that an underlying structural alteration of glomerular architecture


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