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Malabsorption in Intestinal Scleroderma: Relation to Bacterial Flora and Treatment with Antibiotics

Ann Intern Med. 1966;64(4):834-841. doi:10.7326/0003-4819-64-4-834
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Small-intestinal involvement in scleroderma has received increasing attention in recent years. Both the radiologic and pathologic features have been described in detail. Segmental dilatation of the jejunum and descending duodenum and delayed intestinal transit are the main radiologic findings (1, 2). Atrophy and fragmentation of the muscular coats with increased deposition of collagen are characteristic histologic features (3, 4); the mucosa is essentially intact (5). Rosson and Yesner (6) recently reported increased deposition of collagen around and between the lobules of Brunner's glands.

Despite the relative frequency of small-intestinal involvement in scleroderma (1, 2, 4) only 11 cases have been


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