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Surreptitious Ingestion of Coumarin Anticoagulant Drugs

ROBERT A. O'REILLY, M.D., F.A.C.P.; and PAUL M. AGGELER, M.D., F.A.C.P.
Ann Intern Med. 1966;64(5):1034-1041. doi:10.7326/0003-4819-64-5-1034
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This excerpt has been provided in the absence of an abstract.

Coumarin and indanedione anticoagulant drugs are commonly used in the treatment of thromboembolic disorders. In addition, they have been used occasionally to accomplish murder (1), to commit suicide (2), or to produce factitious disease (3-7). Rarely, they have been dispensed in error by a pharmacist (8) or have been confused by the patient with other medications (8).

Surreptitious ingestion of an anticoagulant should be suspected in patients who have an unexplained acquired hemorrhagic diathesis associated with low prothrombin complex activity. It should be thought of particularly in persons who have access to coumarin or indanedione compounds, either as medication or

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