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Glucose Tolerance, Plasma Insulin, and Free Fatty Acids in Elderly Subjects

Ann Intern Med. 1966;64(5):1042-1048. doi:10.7326/0003-4819-64-5-1042
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The older an individual on whom a glucose tolerance test is performed, the more likely will the result be abnormal, as judged by standard criteria (1-9). The evidence suggests that this trend intensifies sharply in the seventh decade of life, so much so that questions arise as to the interpretation of glucose tolerance tests in elderly individuals. More fundamental questions relate to the mechanism of the age-related change in blood glucose homeostasis. The elucidation of this phenomenon might well have important theoretical and practical implications for our understanding of both diabetes and aging.

The objective of the present study was


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