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Central Nervous System Infection with Herpesvirus Hominis.

Lloyd C. Olson, M.D.; Malcolm S. Artenstein, M.D. (Associate); Paul D. Parkman, M.D.; and Edward L. Buescher, M.D.
Ann Intern Med. 1966;64(5):1168. doi:10.7326/0003-4819-64-5-1168_2
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Forty-seven patients with herpesvirus associated A with central nervous system (CNS) infections were divided into four groups: (1) 18 cases of encephalitis in which herpesvirus was isolated directly from CNS tissue; (2) 16 instances of encephalitis demonstrating a significant increase of complement-fixing or neutralizing antibody but without virus isolates; (3) 10 cases of aseptic meningitis associated with antibody rise; and (4) 3 patients with atypical illnesses with CNS symptoms who demonstrated antibody increase.

Analysis of group 1 revealed a clinical syndrome often beginning with fever and headache, CNS symptoms developing within 5 days. Nuchal rigidity, disturbances in consciousness and motor


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