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Treatment of Bacterial Endocarditis in Patients with Penicillin Hypersensitivity.

George R. Green, M.D.; Gustavus A. Peters, M.D., F.A.C.P.; and Joseph E. Geraci, M.D., F.A.C.P.
Ann Intern Med. 1966;64(5):1170. doi:10.7326/0003-4819-64-5-1170_1
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Seventy-one of 400 patients treated for bacterial endocarditis (1951 through 1964) had a history of penicillin allergy (18%). Allergic reactions occurred in 22 of 56 such patients receiving penicillin (39%); 18 patients without allergic history had reactions to penicillin (5%). No reaction was fatal, but one patient had an anaphylactic reaction. In 5 of 22 patients in the allergic group and in 5 of 18 in the nonallergic group, penicillin therapy was discontinued because of severe reactions but was successfully completed in the others, the delayed allergic reaction being controlled by steroids or antihistamines or both. Little correlation was noted


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