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The Renal Excretion of Hydrogen Ion in Patients with Uric Acid Calculi.

Abraham Rapoport, M.D., F.A.C.P.; Peter O. Crassweller, M.D.; Harry Husdan, Ph.D.; Morton Zweig, M.D.; and Michael D. Johnson, M.D.
Ann Intern Med. 1966;64(5):1173. doi:10.7326/0003-4819-64-5-1173_1
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In an effort to explain the pathogenesis of uric acid calculi, observations have been made on 16 patients with renal uric acid calculi, and, as controls, on 16 patients with calcium oxalate calculi and 11 normal subjects. All patients were studied in the Metabolic Unit after at least a 3-day intake of a neutral ash diet. All were free of infection, off drugs and nonazotemic. The blood urea nitrogen and creatinine clearances were comparable in both patient groups. Hydrogen ion and organic acid excretion were then compared in 24-hour urines collected under basal conditions. The urine pH of the uric


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