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Abstracts |

Glucagon Secreting Pancreatic Tumor: A New Entity.

Marvin E. Levin, M.D., F.A.C.P.; Lillian Recant, M.D.; Charles Kilo, M.D.; Malcolm McGavran, M.D.; and Roger H. Unger, M.D.
Ann Intern Med. 1966;64(5):1176-1177. doi:10.7326/0003-4819-64-5-1176_2
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Functional islet cell tumors have been described in association with syndromes of hypersecretion of insulin and possibly gastrin. To date no instance of a functioning alpha cell tumor secreting glucagon, the hyperglycemic-glycogenolytic hormone of the alpha cell, has been documented. The first such case demonstrated by electron-microscopy and specific radioimmunoassay, is the subject of this report.

A 42-year-old white female presented with dermatitis, diabetes, and mild anemia. There was no known family history of diabetes. Resistant dermatitis, the major clinical problem, proved not to be of fungal origin. Diabetes was easily controlled by diet. Eighteen months later hepatomegaly was noted.


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