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Abstracts |

Fibrotic Conditions Occurring During Methysergide Therapy for Headache.

John R. Graham, M.D., F.A.C.P.; and Howard I. Suby, M.D.
Ann Intern Med. 1966;64(5):1184. doi:10.7326/0003-4819-64-5-1184_2
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Twente-seven patients who have developed retroperitoneal fibrosis while taking methysergide (Sansert®) for headache have been collected. In 14 patients the diagnosis was proved at operation. In 13 it was clinically established, and the process regressed upon withdrawal of the drug. Fibrosis involving the root of the aorta, heart valves, and pulmonary tissue during methysergide therapy will also be discussed and theories presented regarding the possible relationship of the drug to these conditions and the possible mechanisms involved.


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