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The Use of Epsilon Amino Caproic Acid in the Treatment of Progressive Systemic Sclerosis.

Jerome Rotstein, M.D.; Donald Golden, M.D.; Frederick A. Reiss, M.D.; Adriano Lauriello, M.D.; and Michel Bourel, M.D.
Ann Intern Med. 1966;64(5):1185. doi:10.7326/0003-4819-64-5-1185_2
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Epsilon amino caproic acid is an antifibrinolytic agent that is related to the amino acid lysine, but it has the unique action of the indirect and direct inhibition of plasmin, thus preventing fibrinolysis. In relatively high concentrations it is an inhibitor of the proteolytic action of trypsin and pepsin. In moderate concentrations it prevents many immediate and delayed hypersensitivity reactions. It is almost totally excreted in an unchanged form within 6 hours through the kidney. These properties provide the drug with anti-inflammatory, anti-allergic, and diuretic actions.

Progressive systemic sclerosis is a generalized disease of the connective tissue that is manifested


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