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Renal Failure with Cirrhosis: Observations on the Role of Diuretics

Ann Intern Med. 1966;64(6):1221-1228. doi:10.7326/0003-4819-64-6-1221
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Since the paper of Hecker and Sherlock (1) in 1956, renal failure developing in a setting of cirrhosis with ascites has received increasing attention (2-4). It is distinguished by the lack of such precipitating factors as gastrointestinal hemorrhage, sepsis with shock, and common renal and hepatic toxins or infectious agents known to induce renal failure. Because of the lack of consistent histologic renal abnormalities, Vesin (5) has used the term "functional" to describe this renal failure. Although it is possible that functional renal failure has been partially overlooked in the past and its true prevalence underestimated, it is also possible


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