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Splenectomy in Felty's Syndrome

ROBERT A. GREEN, M.D.; and VINCENT L. FROMKE, M.D.
Ann Intern Med. 1966;64(6):1265-1270. doi:10.7326/0003-4819-64-6-1265
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Splenomegaly occurs in uncomplicated rheumatoid arthritis in about 5 to 10% of patients, but the association of splenomegaly, arthritis, and leukopenia, known as Felty's syndrome, is quite rare, perhaps in the range of 1 in 300 cases of rheumatoid arthritis. Anemia and occasionally thrombocytopenia may also occur, and these cytopenias have most often been explained as being due to hypersplenism. Hypersplenism is an uncertain concept at best, and in a pathologic condition such as rheumatoid arthritis, the relationship of the enlarged spleen and abnormalities in the blood should be considered cautiously. This is particularly true when it comes to the

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