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Globulin Synthesis by Human Peripheral Lymphocytes: In Vitro Measurements Using Lymphocytes from Normals and Patients with Disease

Ann Intern Med. 1966;65(1):69-79. doi:10.7326/0003-4819-65-1-69
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Recent studies have provided evidence that circulating lymphocytes may synthesize globulin in vitro (1-3). Furthermore, there is good evidence that at least some of this globulin may be antibody (4-6). Globulin synthesis may be stimulated by phytohemagglutinin (2-3).

Protein synthesis by human lymphocytes may be quantitated in vitro by measuring, under standard conditions, the incorporation of 14C-labeled amino acids into protein (3). These studies have indicated that the capacity of lymphocytes to synthesize globulin in vitro may differ considerably in certain disease states from that observed in normal subjects. Observations are reported in this paper on the function of leukocytes


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