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Metabolic Abnormalities of Lactic Acid in Burkitt-type Lymphoma with Malignant Effusions

Ann Intern Med. 1966;65(1):101-108. doi:10.7326/0003-4819-65-1-101
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Elevations of blood lactic acid rarely are observed in patients with cancer uncomplicated by shock or hypoxia. However, Field, Block, and Rall (1) and Field, Block, Levin, and Rall (2) noted an occasional relationship between extensive leukemia and development of clinical lactic acidosis. They suggested that lactic acid produced by leukemic tissue may be the cause of such a metabolic disorder although leukemic cells are paradoxically characterized by low in vitro rates of glycolysis (2-6), in contrast to most malignant neoplasms (7-10).

Recently, a patient with "Burkitt's lymphoma" was admitted to the National Cancer Institute. The initial manifestations of the


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