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Aortic Valve Disease and Hemolytic Anemia

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Copyright ©, 1966, by The American College of PhysiciansThe American College of Physicians

Ann Intern Med. 1966;65(2):203-209. doi:10.7326/0003-4819-65-2-203
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The postoperative syndrome of anemia, hemoglobinemia, hemosiderinuria, and a characteristic poikilocytosis (schistocytes) has been observed since the widespread use of endocardial prostheses. Hematocrit volumes in operative subjects decreased after implacement of the Hufnagel ball valve (1), and the syndrome was subsequently produced in dogs with Hufnagel valves (2, 3). Since then, many reports of this complication have appeared, nearly all concerning aortic valve replacements or Teflon repairs of ostium primum defects. Hemolysis was discovered in many of these patients when convalescence was disrupted by avulsion of the valve prosthesis from its muscle attachment (4, 5) torn prosthetic valve cusps (6),


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