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The Treatment of Acute Thrombotic Thrombocytopenic Purpura with Corticosteroids and Splenectomy: Report of Three Cases

Ann Intern Med. 1966;65(2):245-251. doi:10.7326/0003-4819-65-2-245
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Since Moschowitz (1) published the first description of thrombotic thrombocytopenic purpura in 1925, case reports of this entity have appeared with increasing frequency in the medical literature. Over 270 cases have been reported in the world literature (2). The disease is diagnosed postmortem more frequently than antemortem and is still considered by many to be nearly uniformly fatal with no effective treatment (3-5). However, a small number of patients have been reported who have survived after treatment with corticosteroids and splenectomy (6).

The purpose of this report is to report three additional patients treated with massive hormonal therapy and splenectomy.


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