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Hereditary Addison's Disease and Multiple Endocrine Adenomatosis in a Kindred: Autoimmune Aspects

JAMES C. MERSHON, M.D.; and JOHN G. DIETRICH, M.D.
Ann Intern Med. 1966;65(2):252-258. doi:10.7326/0003-4819-65-2-252
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Recently, multiple endocrine disorders in individuals have been reported with increasing frequency (1-7). This report describes a kindred with adrenal carcinoma and multiple endocrine adenomatosis in the mother and Addison's disease in four of her children. Antibody studies are reported, and evidence is presented that supports the concepts of genetically determined predisposition to autoimmunity and of polyglandular immunity.

METHODS: The urinary 17-hydroxy and 17-ketogenic steroid determinations in Case 4 (L. M.) were performed by a modification of the method of Silber and Porter (8). The urinary 17-ketogenic determinations in Case 5 (V. H.) were performed by the Norymberski method (9).

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