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Benign Recurrent Intrahepatic Cholestasis in Two Brothers: A Clinical, Light, and Electron Microscopy Study

Ann Intern Med. 1966;65(2):330-341. doi:10.7326/0003-4819-65-2-330
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Benign recurrent intrahepatic cholestasis is a recently described disorder (1) characterized by attacks of jaundice with obstructive features recurring over a number of years. Though the etiology is obscure, the coincidence in two boys, possibly related (2), and in two brothers (3) suggests that this may be a constitutional form of jaundice. In some cases (1, 4-6), inquest or examination of the families were negative, and according to Williams and associates (6), the evidence for an acquired or genetic defect is far from conclusive.

Summerskill (7) concluded in 1965 that eight cases had been published so far. But adding 2


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