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Severe Mechanical Hemolytic Anemia Due to Valvular Heart Disease Without Prosthesis

Ann Intern Med. 1966;65(2):342-346. doi:10.7326/0003-4819-65-2-342
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Anemia, after the replacement of a damaged heart valve, was first reported in 1954 when Rose and associates (1) described it after the insertion of a prosthetic valve of the Hufnagel type in the descending aorta for correction of aortic insufficiency. Hemolysis after open heart surgery was reported in dogs by Stohlman, Sarnoff, Case, and Ness (2) after the insertion of a prosthetic valve (Hufnagel type) encased in a lucite tube into the thoracic aorta. Later, Sayed and associates (3) observed the phenomenon in one patient after insertion of a Teflon patch for correction of atrial septal defect. Although subsequently


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