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Light-chain Disease: An Abortive Variant of Multiple Myeloma

RALPH C. WILLIAMS JR., M.D.; RICHARD D. BRUNNING, M.D.; and FRANK A. WOLLHEIM, M.D.
Ann Intern Med. 1966;65(3):471-486. doi:10.7326/0003-4819-65-3-471
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Twenty-one per cent of 110 myeloma patients studied showed relative hypogammaglobulinemia by ordinary electrophoresis. Nine of ten living patients showed marked elevations of free serum L-chains (see Table 1) predominantly of one major L-chain type. Myeloma patients with sharp serum M-components also showed free serum L-chains and in 11%, concentrations of the same order of magnitude as was the case in the hypogammaglobulinemic patients. Attempts to detect the presence of small quantities of whole 7S myeloma protein by Gm character, immunologic deficiency, or H-chain subgrouping of gamma globulin fractions of hypogammaglobulinemic sera were generally unsuccessful. Two of ten patients studied

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