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Original Research |

Membranous Glomerulonephritis in Two Human Renal Homotransplants

Ann Intern Med. 1966;65(3):504-510. doi:10.7326/0003-4819-65-3-504
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Healthy kidneys transplanted to an identical twin who suffers from chronic glomerulonephritis frequently show the signs and morphology of chronic glomerulonephritis (1-3). In these cases there seems to have been a recrudesence of a diffuse glomerulonephritis which was previously active in the recipient. It has been suggested that some nephritogenic substance, possibly circulating antibody, contributes to the activity of the disease in the transplant. Prophylactic nephrectomy has been advocated because such a substance might be specifically related to the diseased renal tissue (1). In contrast, glomerulonephritis occurring in homotransplants treated continuously with immunosuppressive drugs to avoid rejection is distinctly rare.


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