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Severe Diarrhea Controlled by Gamma Globulin in a Patient with Agammaglobulinemia, Amyloidosis, and Thymoma

HAROLD O. CONN, M.D.; and RICHARD QUINTILIANI, M.D.
Ann Intern Med. 1966;65(3):528-541. doi:10.7326/0003-4819-65-3-528
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The description of agammaglobulinemia by Bruton (1) in 1952 initiated reports of a variety of hypoagammaglobulinemic syndromes and stimulated an enormous amount of research in infectious disease and immunology. Among the clinical variants of hypogammaglobulinemia reported were sprue-like syndromes, anemias of diverse type, and a high prevalence of thymoma. The present report concerns a patient with adult-onset, "acquired" hypogammaglobulinemia who had severe diarrhea which was controlled by the administration of gamma globulin. In addition, amyloidosis and a thymoma were found at autopsy. The purpose of this paper is to define possible relationships among these abnormalities by reviewing the previously reported

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