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Studies on the Epidemiology of Adverse Drug Reactions: V. Clinical Factors Influencing Susceptibility

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Copyright ©, 1966, by The American College of PhysiciansThe American College of Physicians

Ann Intern Med. 1966;65(4):629-640. doi:10.7326/0003-4819-65-4-629
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Adverse pharmacological effects or allergic reactions produced by drugs are determined not only by differences among drugs but also by differences among individuals. Some of the personal or clinical variables and factors influencing drug effects are known, but for the most part it has not been possible to predict which patients are most likely to have adverse reactions after administration of a drug or drugs. The epidemiological studies reported here have been done to examine these personal variables or clinical factors which may be responsible for predisposition to the untoward effects of drugs. The observations define some of these factors,


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