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On the Question of Obstruction in Idiopathic Hypertrophic Subaortic Stenosis

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Cardiology Branch
National Heart Institute
National Institutes of Health
Bethesda, Md.

Ann Intern Med. 1966;65(4):859-861. doi:10.7326/0003-4819-65-4-859
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Only 10 years have elapsed since the concept of functional obstruction to left ventricular ejection was introduced to clinical medicine (1), and in the interim the features of obstructive cardiomyopathy, or idiopathic hypertrophic subaortic stenosis, have become generally recognized. It seems certain that the increasingly frequent recognition of this disease has resulted largely from wider application of left heart catheterization techniques; nevertheless, while the diagnosis initially was based on hemodynamic features peculiar to this disease, it has become possible with increasing experience to recognize and assess the severity of this lesion on clinical grounds alone (2).

Work originating in a


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