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Vascular Headaches and Oral Contraceptives

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University of Miami
Miami, Fla.

Ann Intern Med. 1966;65(4):863. doi:10.7326/0003-4819-65-4-863_1
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Various syndromes have been described as occurring in women in association with the use of oral contraceptives. These include phlebothrombosis, vascular headaches, cerebral arterial and venous occlusive disease, papilledema, oculomotor palsies, and seizures (1-5). Statistical evidence denoting a causal relationship between the progestational steroids and these phenomena is lacking, but a causal association seems likely in the case of vascular headaches.

Our present material includes almost 50 women who developed or had reoccurrence of classical symptoms of migraine while taking progestational steroids. The typical vascular headache was preceded by visual, sensory or motor prodromata in about half the cases. About


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