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Original Research |

Shock, Seizures, and Coma with Alkalosis During Mechanical Ventilation

Ann Intern Med. 1966;65(5):977-984. doi:10.7326/0003-4819-65-5-977
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Effective therapy for patients with severe repiratory failure has produced new hazards which include increased acidosis during oxygen administration (1), pneumonia from breathing aerosols from contaminated nebulizers (2), cardiac arrhythmias associated with rapid reduction of carbon dioxide tension (3, 4), and hypochloremic alkalosis from rapid removal of carbon dioxide in chloride-depleted patients (5-7). Deterioration of mental and neurologic function has been associated frequently with increased acidosis due to reduction of alveolar ventilation (8-10). Recently confusion, seizures, and shock have been described in patients with severe alkalosis due to mechanical hyperventilation (6, 11, 12).

That severe alkalosis as well as severe


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