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Iatrogenic Asthma Associated with Adrenergic Aerosols

Ann Intern Med. 1966;65(5):985-995. doi:10.7326/0003-4819-65-5-985
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Because of their speed and effectiveness sympathomimetic aerosols have become established as one of the mainstays in the management of the reversible component of diffuse airway obstruction. Although the early clinical application of these aerosols is almost entirely based on short-term challenge experiments often conducted in normal subjects, there is now a tendency to study the response of asthmatic patients over more prolonged periods of time (1-4). The recognized side effects of sympathomimetic aerosols (5) are generally attributable to excessive systemic absorption, and sudden death may occur in the asthmatic when adrenergic drugs are used to excess (6-8). In addition,



asthma ; aerosols

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