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Quinacrine (Atabrine®) in the Treatment of Neoplastic Effusions

MALIN R. DOLLINGER, M.D.; IRWIN H. KRAKOFF, M.D., F.A.C.P.; and DAVID A. KARNOFSKY, M.D., F.A.C.P.
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Copyright ©, 1967, by The American College of PhysiciansThe American College of Physicians


Ann Intern Med. 1967;66(2):249-257. doi:10.7326/0003-4819-66-2-249
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Quinacrine (Atabrine®) inhibited the growth of several transplanted solid tumors (1) and of the Ehrlich ascites tumor in mice (when it was given intraperitoneally) (2). It was cytotoxic to a variety of normal and tumor cells grown in tissue culture (3). In a variety of experimental tumors and in man cytotoxic levels comparable to those effective against tumor cells in tissue culture could not be achieved without unacceptable host toxicity. By local instillation into serous cavities, high local concentrations of quinacrine were obtained. When used clinically, it was found by Gellhorn, Zaidenweber, Ultmann, and Hirschberg (2) and by Ultmann, Gellhorn,

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Topics

quinacrine ; effusion

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