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Quantitative Displacement of Acid-Base Equilibrium in Metabolic Acidosis

Ann Intern Med. 1967;66(2):312-322. doi:10.7326/0003-4819-66-2-312
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Metabolic acidosis is commonly encountered in a variety of disorders, all of which are characterized either by the gain of strong acid or by loss of bicarbonate from the extracellular fluid (1). In either case, the primary effect upon the acid-base composition of blood is a fall in the concentration of the metabolic component, and this can be measured either by a change in the concentration of whole blood buffer base (that is, the base excess, which in this case assumes a negative value) or by a fall in the concentration of bicarbonate in the plasma or both. Given this


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