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The Role of Acute Lower Respiratory Infection in Causing Pulmonary Insufficiency in Bronchiectasis

NEIL S. CHERNIACK, M.D.; HARRY F. DOWLING, M.D., F.A.C.P.; ROBERT W. CARTON, M.D., F.A.C.P.; and VERA E. MCBRYDE, M.D.
Ann Intern Med. 1967;66(3):489-497. doi:10.7326/0003-4819-66-3-489
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This excerpt has been provided in the absence of an abstract.

Although effective antimicrobial treatment has reduced the prevalence of fulminating infections in patients with bronchiectasis, repeated and protracted episodes of acute lower respiratory infection continue to occur in certain individuals. Not only are these episodes a severe economic burden to the patient, but, more significantly, they may produce permanent lung damage. Since respiratory insufficiency, manifested functionally by bronchial obstruction and unequal ventilation-perfusion ratios, is commonly observed in patients with bronchiectasis, further deterioration of lung function would be expected to affect prognosis adversely (1, 2).

We have analyzed the data on 63 patients with established bronchiectasis to determine whether repeated or

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