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Desquamative Interstitial Pneumonia: A Disease with a Wide Clinical Spectrum

ROBERT A. KLOCKE; WILLIAM S. AUGERSON; HOWARD H. BERMAN; FRANCISCO L. BURGOS; and RAPHAEL A. RIVERA
Ann Intern Med. 1967;66(3):498-506. doi:10.7326/0003-4819-66-3-498
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Since the original description of desquamative interstitial pneumonia by Liebow, Steer, and Billingsley (1), other investigators have added carefully studied series to the literature (2, 3). The original 18 cases were all dyspneic, and the majority had persistent cough and varying degrees of cyanosis, clubbing, and chest pain. Steinberg (2) added 3 cases, all unequivocably disabled. Two responded to surgical removal of localized involved lung tissue, and the third died after prolonged corticosteroid therapy. The analysis of 12 cases by Gaensler, Goff, and Prowse (3) included selected instances of a more benign course documented with long-term follow-up, departing from the

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